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Golgi apparatus: structure, vesicular transport versus cisternal maturation model, protein transport | Light and electron microscopic visualization of the Golgi apparatus, three-dimensional structure of the Golgi apparatus, topographical-functional aspects of Golgi traffic, histochemical compartment markers, Golgi resident proteins, functional Golgi compartments, shape-forming proteins, formation of COPI vesicles, retrograde Golgi-to-ER transport, intra-Golgi transport | ![]() |
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Lee SY, Yang JS, Hong WJ, Premont RT, Hsu VW:ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J Cell Biol 168:281, 2005 | Presentation of an original scientific publication by a student. Discussion by all students of the class and conclusions. | ![]() |
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Golgi apparatus: N- and O-glycosylation and Golgi apparatus: trans-Golgi network, trans-Golgi ER | Golgi mannosidases, glycosyltransferases, endomannosidase, nucleotide sugar transporter, N-glycans, O-glycans, polypeptide-GalNAc transferase, sialic acid, polysialic acid, NCAM, Tn antigen, TF antigen Trans-Golgi-network, endoproteases, clathrin-coated vesicles, caveolin, AP3, AP4, sialyltransferase, protein sorting, TGN38, proton pumps, insulin maturation, lipid transfer |
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Chen C, Ma JY, Lazic A, Backovic M, Colley KJ: Formation of insoluble oligomers correlates with ST6G | Golgi apparatus, alpha 2,6 sialyltransferase, protein dimerization Cystic fibrosis, protein folding, synthetic chaperone | ![]() |
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Endoplasmic reticulum and Golgi apparatus: experimental manipulation of membrane traffic | vesicular transport, ER, Golgi apparatus, microtubule depolymerization, colchicine, nocodazole, siRNA knockdown, temperature blockade, membrane fluidity, membrane lipids, cholesterol, monensin, Brefeldin A, Illimaquinone, perforated cells | ![]() |
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Endoplasmic reticulum and Golgi apparatus: experimental manipulation of membrane traffic | vesicular transport, ER, Golgi apparatus, microtubule depolymerization, colchicine, nocodazole, siRNA knockdown, temperature blockade, membrane fluidity, membrane lipids, cholesterol, monensin, Brefeldin A, Illimaquinone, perforated cells * 해당강의는 동영상 촬영 시부터 마이크의 호환 문제로 강의시작 15분 이후부터 교수자 음성이 녹음 되지 못하였습니다. |
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Tartakoff: Temperature and energy dependence of secretory protein transport in the exocrine pancreas | vesicular transport, temperature, membrane fluidity, ER, Golgi apparatus | ![]() |
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Lippincott-Schwartz et al.: Rapid redistribution of Golgi proteins into the ER in cells treated with | vesicular transport, Brefeldin A, Golgi apparatus, ER, membrane tubules | ![]() |
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Lysosomes: Structure and biosynthesis, M6P receptors and sorting | Structure and function of lysosomes, techniques to visualize lysosomes in cells by light and electron microscopy, biogenesis of lysosomes and biosynthesis of mannose-6-phosphate recognition marker, structure and function of lysosomalmembrane proteins, sorting and targeting of lysosomal enzymes in lysosomes, structure and function of mannose-6-phosphate receptors | ![]() |
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Lysosomes: Structure and biosynthesis, M6P receptors and sorting | Structure and function of lysosomes, techniques to visualize lysosomes in cells by light and electron microscopy, biogenesis of lysosomes and biosynthesis of mannose-6-phosphate recognition marker, structure and function of lysosomalmembrane proteins, sorting and targeting of lysosomal enzymes in lysosomes, structure and function of mannose-6-phosphate receptors * 해당강의는 동영상 촬영 시부터 마이크의 호환 문제로 강의시작 6분 이후부터 교수자 음성이 녹음 되지 못하였습니다. |
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Kundra R and Kornfeld S (1999) Asparagine-linked oligosaccharides protect Lamp-1 and Lamp-2 from ntracellular proteolysis. J Biol Chem 274: 18966. | Presentation and discusssion of a scientific publication on the function of lysosomal membrane proteins | ![]() |
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Reczek et al. (2007) LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell 131: 770. | Presentation and discusssion of a scientific publication on the mannose-6-phosphate-independent targeting of lysosomal enzymes | ![]() |
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Lysosomes: Biological significance, lysosomal disorders Autophagy: biogenesis of autophagosomes, markers of autophagy | Sorting pathways of lysosomal enzymes, structure and function of the lysosomal proton pump, biological significance of lysosomal digestion, lysosomal lipid digestion, structure and function of GlcNAc-1-phosphotransferase, lysosomal diseases, molecular pathogenesis of I-cell disease, molecular pathogenesis and cellular consequences of Fabry disease, autophagy, Atg genes and proteins, biogenesis of authophagosomes and autolysosomes, LC3 as a autophagosome marker | ![]() |
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Lysosomes: Biological significance, lysosomal disorders Autophagy: biogenesis of autophagosomes, markers of autophagy | Sorting pathways of lysosomal enzymes, structure and function of the lysosomal proton pump, biological significance of lysosomal digestion, lysosomal lipid digestion, structure and function of GlcNAc-1-phosphotransferase, lysosomal diseases, molecular pathogenesis of I-cell disease, molecular pathogenesis and cellular consequences of Fabry disease, autophagy, Atg genes and proteins, biogenesis of authophagosomes and autolysosomes, LC3 as a autophagosome marker | ![]() |
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Proteasome: Molecular assembly and structure, recognition and degradation of misfolded lycoproteins, regulation of short lived cytosolic and nuclear proteins, proteasome inhibitors | phylogeny of proteasomes, molecular composition, structure and function of 26S proteasomes, function of proteasomal subunits, assembly of proteasomes, subcellular distribution of proteasomes, the proteasome ubiquitin system, ESCORT pathway, proteasomal substrates, proteasome inhibitors, | ![]() |
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Ng et al. (2007). Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum. J Cell Sci 120, 682. Guzman et al. (2002). Preferential induction of apoptosis for primary human leukemic stem cells. PNAS 99, 16220. | Presentation and discusssion of a scientific publication on the interaction between proteasomes and the ER membrane. Presentation and discusssion of a scientific publication on the Presentation and discusssion of a scientific publication on the use of proteasome inhibition for cancer treatment | ![]() |