약리학
- 건국대학교
- 강학수
페이스북
트위터
카카오톡
네이버밴드
링크복사
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- 의약학 >약학 >약학
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- 강의학기
- 2017년 2학기
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- 조회수
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- 평점
- 3.5/5.0 (2)
- 강의계획서
- 강의계획서
점차 전세계의 인구가 고령화에 접어들면서 앞으로 의학시장의 규모는 지속적으로 증가할 것으로 예측되어집니다. 따라서 새로운 차세대 신약 개발의 중요성도 지속적으로 증가하고 있습니다. 본 수업에서는 신약개발에 필요한 지식인 약이 어떻게 작용하는지에 대해 이해하는 것을 목표로 합니다.
- 수강안내 및 수강신청
- ※ 수강확인증 발급을 위해서는 수강신청이 필요합니다
2. Introduction to drugtargets and molecularpharmacology
차시별 강의
| 1. | |
2. Introduction to drugtargets and molecularpharmacology | Pharmacology introduction, The nature of drug targets |  |
| 2. | |
2. Introduction to drugtargets and molecularpharmacology | Pharmacology introduction, The nature of drug targets | |
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3. Molecular cloning of drug targets | The relevance of recombinant DNA technology to pharmacology/drug discovery | |
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Molecular cloning of drug targets, Agonist selectivity | The cloning of drug targets | |
| 5. | |
Agonist selectivity, Affinity, Efficacy | Agonist selectivity, Affinity, Efficacy | |
| 6. | |
Efficacy, Drugs with multiple efficacies, Quantifying agonist activity, Bi-Molecular Systems, What is drug antagonism | Efficacy, Drugs with multiple efficacies, Quantifying agonist activity, Bi-Molecular Systems, What is drug antagonism | |
| 7. | |
What is drug antagonism, Antagonist potency, Mechanism of receptor antagonism, Competitive and non-competitive antagonism | What is drug antagonism, Antagonist potency, Mechanism of receptor antagonism, Competitive and non-competitive antagonism | |
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Orthosteric antagonist,Competitive and non-competitive antagonism | Orthosteric antagonist,Competitive and non-competitive antagonism | |
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Characteristic properites of allosteric molecules and how they interact with proteins | 1. Introduction 2. protein allosterism 3. types of allosteric modulators 4. Unique effects of allosteric modulators 5. Detecting allosterism 6. Summary | |
| 10. | |
Introduction to molecularpharmacology, G-protein coupled receptors | G-protein coupled receptors, Ion channels | |
| 11. | |
Ion Channels, Nuclear receptors, Transporters | Ion Channels, Nuclear receptors, Transporters | |
| 12. | |
Molecular Pharmacology | GPCR | |
| 13. | |
Molecular Pharmacology | GPCR | |
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Signal transduction pathway, Desensitization and down-regulation of GPCR signaling, Constitutive GPCR activity | Signal transduction pathway, Desensitization and down-regulation of GPCR signaling, Constitutive GPCR activity | |
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Promiscuous G protein coupling, Agonist-directed signalling, Allosteric modulators of GPCR function, Pharmacological chaperones for GPCRs | Promiscuous G protein coupling, Agonist-directed signalling, Allosteric modulators of GPCR function, Pharmacological chaperones for GPCRs | |
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Pharmacological chaperones for GPCRs, GPCR dimerization, GPCR splice variants | Pharmacological chaperones for GPCRs, GPCR dimerization, GPCR splice variants | |
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GPCR dimerization | Methods to study GPCR dimerzation, Homodimerization, Heterodimerization | |
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Class C GPCR | Class C GPCR | |
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GPCR splice variants have an influence on GPCR pharmacology | GPCR splice variants have an influence on GPCR pharmacology | |
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GPCR drug examples, Voltage-gated ion channels | GPCR drug examples, Voltage-gated ion channels | |
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Voltage-gated ion channels | Voltage-gated ion channels | |
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Voltage-gated ion channels, Ligand-gated ion channels | Voltage-gated ion channels, Ligand-gated ion channels | |
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Ligand-gated ion channels | Ligand-gated ion channels | |
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