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강의학기

2017년 2학기

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17,063
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강의계획서

점차 전세계의 인구가 고령화에 접어들면서 앞으로 의학시장의 규모는 지속적으로 증가할 것으로 예측되어집니다. 따라서 새로운 차세대 신약 개발의 중요성도 지속적으로 증가하고 있습니다. 본 수업에서는 신약개발에 필요한 지식인 약이 어떻게 작용하는지에 대해 이해하는 것을 목표로 합니다.

수강안내 및 수강신청
※ 수강확인증 발급을 위해서는 수강신청이 필요합니다

2. Introduction to drugtargets and molecularpharmacology

차시별 강의

1.	2. Introduction to drugtargets and molecularpharmacology	Pharmacology introduction, The nature of drug targets
2.	2. Introduction to drugtargets and molecularpharmacology	Pharmacology introduction, The nature of drug targets
3.	3. Molecular cloning of drug targets	The relevance of recombinant DNA technology to pharmacology/drug discovery
4.	Molecular cloning of drug targets, Agonist selectivity	The cloning of drug targets
5.	Agonist selectivity, Affinity, Efficacy	Agonist selectivity, Affinity, Efficacy
6.	Efficacy, Drugs with multiple efficacies, Quantifying agonist activity, Bi-Molecular Systems, What is drug antagonism	Efficacy, Drugs with multiple efficacies, Quantifying agonist activity, Bi-Molecular Systems, What is drug antagonism
7.	What is drug antagonism, Antagonist potency, Mechanism of receptor antagonism, Competitive and non-competitive antagonism	What is drug antagonism, Antagonist potency, Mechanism of receptor antagonism, Competitive and non-competitive antagonism
8.	Orthosteric antagonist,Competitive and non-competitive antagonism	Orthosteric antagonist,Competitive and non-competitive antagonism
9.	Characteristic properites of allosteric molecules and how they interact with proteins	1. Introduction 2. protein allosterism 3. types of allosteric modulators 4. Unique effects of allosteric modulators 5. Detecting allosterism 6. Summary
10.	Introduction to molecularpharmacology, G-protein coupled receptors	G-protein coupled receptors, Ion channels
11.	Ion Channels, Nuclear receptors, Transporters	Ion Channels, Nuclear receptors, Transporters
12.	Molecular Pharmacology	GPCR
13.	Molecular Pharmacology	GPCR
14.	Signal transduction pathway, Desensitization and down-regulation of GPCR signaling, Constitutive GPCR activity	Signal transduction pathway, Desensitization and down-regulation of GPCR signaling, Constitutive GPCR activity
15.	Promiscuous G protein coupling, Agonist-directed signalling, Allosteric modulators of GPCR function, Pharmacological chaperones for GPCRs	Promiscuous G protein coupling, Agonist-directed signalling, Allosteric modulators of GPCR function, Pharmacological chaperones for GPCRs
	Pharmacological chaperones for GPCRs, GPCR dimerization, GPCR splice variants	Pharmacological chaperones for GPCRs, GPCR dimerization, GPCR splice variants
	GPCR dimerization	Methods to study GPCR dimerzation, Homodimerization, Heterodimerization
	Class C GPCR	Class C GPCR
	GPCR splice variants have an influence on GPCR pharmacology	GPCR splice variants have an influence on GPCR pharmacology
	GPCR drug examples, Voltage-gated ion channels	GPCR drug examples, Voltage-gated ion channels
	Voltage-gated ion channels	Voltage-gated ion channels
	Voltage-gated ion channels, Ligand-gated ion channels	Voltage-gated ion channels, Ligand-gated ion channels
	Ligand-gated ion channels	Ligand-gated ion channels

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운영자2019-01-11 09:22: 강의교재는 Molecular Pharmacology. From DNA to Drug Discovery, John Dickenson et al. 저, Wiley-Blackwell 입니다. 자세한 강의교재정보는 강의계획서를 참고하여 주시기 바랍니다.