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    의약학 >약학 >약학
  • 강의학기
    2017년 2학기
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강의계획서
강의계획서
This course will provide students with a basic understanding of principles and applications of controlled drug delivery systems. To this end, it will focus on topics including physicochemical and biological barriers, drug delivery pathways, metabolism, drug formulation, pharmacokinetic and pharmacodynamic issues. It will expand the coverage to reflect latest updates and advances in materials for delivery vehicles, drug delivery approaches, and therapeutics.
Factors that Impact the Developability of Drug Candidates
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1. Factors that Impact the Developability of Drug Candidates 1. Challenges Facing the Pharmaceutical Industry 2. Factors that Impact Developability 3. Remarks on Developability 4. Drug Delivery Factors that Impact Developability URL
2. Physiological, Biochemical, andChemical Barriers to Oral Drug Delivery Introduction
1. Physiological Barriers to Drug Delivery
2. Biochemical Barriers to Drug Delivery
URL
3. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery 2. Biochemical Barriers to Drug Delivery
3. Chemical Barriers to Drug Delivery
4. Drug Modifications to Enhance Transport Across Biological Barriers
URL
4. PhysicochemicalProperties, Formulation, and Drug Delivery 1. Physicochemical Properties
2. Formulations
URL
5. PhysicochemicalProperties, Formulation, and Drug Delivery 3. Drug Delivery
1. Target Bioavailability
URL
6. Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Discovery and Development 1. Target Bioavailability
2. Drug Delivery Trends and Targets Related to PK and PD
3. PK?PD in Drug Discovery and Development
4. Source of Variability of Drug Response
URL
7. Targeted Bioavailability :A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Discovery and Development 4. Source of Variability of Drug Response
5. Recent Development and Issues of Bio- Analytical Methodology
6.Mechanistic PK?PD Models
URL
8. The Role of Transporters in Drug Delivery and Excretion 1. Drug Transport in Absorption and Excretion
2. ABC (ATP-Binding Cassette) Transporter Family
URL
9. The Role of Transporters in Drug Delivery and Excretion 3. SlC (Solute Carrier) Transporter Family URL
10. Intracellular Deliveryand Disposition of Small-Molecular Weight Drugs 1. The Relationship between the
Intracellular Distribution of a Drug and its Activity
2. The Relationship between the
Intracellular Distribution of a Drug and its Pharmacokinetic Properties
3. Overview of Approaches to Study Intracellular Drug Disposition
4. The Accumulation of Drugs in
Mitochondria, Lysosomes, and Nuclei
URL
11. Intellectual Property and Regulatory Issues inDrug Delivery Research 1. Pharmaceutical Patents
2. Statutory Requirements for
Obtaining a Patent
3. Patent Procurement Strategies
URL
12. Intellectual Property and Regulatory Issues inDrug Delivery Research 4. Regulatory Regime
5. FDA Market Exclusivities
6. Regulatory and Patent Law Linkage
URL
13. Presystemic and First-Pass Metabolism 1. Hepatic First-Pass Metabolism URL
14. Pulmonary DrugDelivery: PharmaceuticalChemistry and Aerosol Technology 1. Aerosol Technology
2. Disease Therapy
URL
15. Pulmonary DrugDelivery: PharmaceuticalChemistry and Aerosol Technology 1. Aerosol Technology
2. Disease Therapy
URL
Pulmonary DrugDelivery: PharmaceuticalChemistry and Aerosol Technology 2. Disease Therapy
3. Formulation Variables 4. Future Developments
URL
Transdermal Delivery of Drugs Using Patchesand Patchless Delivery Systems 1. Transdermal Patch Delivery Systems
2. Patchless Transdermal Drug
Delivery Systems
URL
Transdermal Delivery of Drugs Using Patchesand Patchless DeliverySystems, Prodrug Approaches toDrug Delivery 2. Patchless Transdermal Drug
Delivery Systems
3. Recent Advances in Transdermal Drug Delivery 1. Basic Concepts: Definition and
Applications
URL
Prodrug Approaches to Drug Delivery 1. Basic Concepts: Definition and
Applications
2. Prodrug Design Considerations
URL
Nanoparticles as DrugDelivery Vehicles 1. General DDV Properties
2. Organic DDVs
3. Inorganic DDVs: Metal- and Silica ]Based Systems
URL
Nanoparticles as DrugDelivery Vehicles 1. General DDV Properties
2. Organic DDVs
3. Inorganic DDVs: Metal- and Silica ]Based Systems
URL

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