바로가기

모두를 위한 열린 강좌 KOCW

주메뉴

강의사진
  • 주제분류
    자연과학 >생물ㆍ화학ㆍ환경 >생명공학
  • 등록일자
    2010.12.21
  • 조회수
    3,100
  •  
Introduction
배속
  • 이전차시
  • 다음차시

차시별 강의

PDF VIDEO SWF AUDIO DOC AX
1. 비디오 Introduction Introduction is given to the entire content of the lecture series, and which books are used and that Refswork can be used to download the slides presented during the lectures. An overview is given about the principal techniques used to study the early secretory pathway and cellular digestive systems. URL
2. 비디오 Endoplasmic reticulum: Structural domains, domain formation and function, shape-forming proteins Cell and organ-specific quantitative aspects/differences for the ER are discussed. The ER domains nuclear envelope and rough ER are presented in terms of structure and function as well pathological changes due to protein accumulation and their consequences. URL
3. 비디오 Ilnuma T, et al.: Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. J Cell Sci 122:1680, 2009Hu J, et al.: Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science 319:1247, 2008 Presentation and discusssion of a scientific publication on the role of syntaxin 18 for rough and smooth endoplasmic reticulum domains. Presentation and discusssion of a scientific publication on form-shaping proteins in the endoplasmic reticulum. URL
6. 비디오 Endoplasmic reticulum:Quality control of protein folding and assembly, protein folding disorders,chemical chaperones, congenital disorders of glycosylation House keeping function of protein quality control.Quality control of protein folding under conditions of excess of misfolded glycoproteins. Recognition and retention of misfolded glycoproteins in the endoplasmic reticulum and pre Golgi intermediates. Glycocodes for protein folding. Calnexin/calreticulin cycle. Importance of EDEM1 and OS-9 for dislocation. URL
7. 비디오 Endoplasmic reticulum:Quality control of protein folding and assembly, protein folding disorders,chemical chaperones, congenital disorders of glycosylation Types of protein folding disorders. Definition, classes, properties and use of synthetic chaperones in protein folding disorders. Alpha-galactosidase A competitive inhibitor for Fabry disease. Phenylbutyric acid as chemical chaperone for myocilin-induced glaucoma. Definition and characterization of loss-of-function and pathological gain-of-function folding disorders. URL
8. 비디오 Endoplasmic reticulum:Quality control of protein folding and assembly, protein folding disorders,chemical chaperones, congenital disorders of glycosylation Dislocation of misfolded glycoproteins by ERAD-L, ERAD-M and ERAD-C. Molecular machines generated by dislocation machinery proteins. Structure and function of EDEM 1 and OS9 for protein dislocation. Mechanism of ubiquitination and dislocation of misfolded glycoproteins. Proteasomal and autophagic degradation. Diseases of glycosylation with emphasis on molecular basis , diagnostic and therapy of congenital diseases of glycosylation. URL
9. 비디오 Transitional endoplasmic reticulum and pre-Golgi intermediates: COP proteins, ER - Golgi transport, COP protein disorders Structure of pre-Golgi intermediates and transport by microtubules. Function of pre-Golgi intermediates in vesicular transport from ER to Golgi apparatus. Transitional elements of the ER and formation of COPII coat and COPII vesicles. URL
10. 비디오 Golgi apparatus: structure, vesicular transport versus cisternal maturation, protein transport in the Golgi apparatus Techniques to visualize the Golgi apparatus in cells and tissues. Structural and 3D-organization of the Golgi apparatus. Topography of Golgi compartments. Importance of the cytoskeleton and peripheral proteins for Golgi apparatus structure. URL
11. 비디오 Golgi apparatus: structure, vesicular transport versus cisternal maturation, protein transport in the Golgi apparatus Formation and assembly of COPI coats and COPI vesicles through Arf1 and COPI coat proteins. COPI vesicle transport in the Golgi apparatus and retrieval to the ER. Mechanisms of intra-Golgi apparatus transport of cargo. URL
12. 비디오 Long, K. R., et al.: Sar1 assembly regulates membrane constriction and ER export. J Cell Biol 190: 115-128, 2010 Presentation and discussion of a publication on Sar1 involvement in ER-to-Golgi apparatus transport URL
13. 비디오 Friedman, J. R., et al.: ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules. J Cell Biol 190: 363-375, 2010 Presentation and discussion of a scientific publication on organelle transport along microtubules URL

연관 자료

loading..

사용자 의견

강의 평가를 위해서는 로그인 해주세요.

이용방법

  • 동영상 유형 강의 이용시 필요한 프로그램 [바로가기]


    ※ 강의별로 교수님의 사정에 따라 전체 차시 중 일부 차시만 공개되는 경우가 있으니 양해 부탁드립니다.

이용조건