1. |
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Introduction to biological membranes |
General description of cell membrane models and their components, lipids and proteins |
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2. |
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The structures and properties of membrane lipids |
Description of structures of major mammalian lipids and their physical and chemical properties |
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3. |
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Lipid biosynthesis and transport |
Description of the biosynthesis of major membrane lipids, different mechanisms of their transport to target membranes, and different lipid compositions of various organelle membranes. |
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4. |
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Cell signaling |
General description of cellular signaling mechanisms with an emphasis on the role of proteins as binary signaling switches |
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5. |
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Lipid signaling1 |
Description of cell signaling by lipids, including phosphoinositides |
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6. |
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Lipid signaling2 |
Description of lipid signaling enzymes, including phospholipases, lipid kinases, lipid phosphatases |
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7. |
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Lipid signaling3 |
Description of cell signaling by phosphatidylinositol-(4,5)-bisphosphate and eicosanoids |
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8. |
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Membrane-binding proteins and membrane-protein interactions |
General description of membrane proteins, including integral and peripheral membrane proteins and the mechanisms by which cellular proteins are recruited to the membranes |
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9. |
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Lipid modification of proteins |
Description of the regulation of membrane interaction of proteins by various lipidation |
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10. |
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Membrane compartmentalization |
Description of the formation of membrane domains, including lipid rafts, and its potential roles in cell regulation |
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