융합구조게놈학

연세대학교
Sung-Hou Kim

페이스북 트위터 카카오톡 네이버밴드 링크복사

주제분류

자연과학 >생물ㆍ화학ㆍ환경 >생물학
강의학기

2011년 2학기

조회수

2,980

Omics approach has profoundly affected all aspects of Life Sciences including genetics, medical genetics, genomics, and proteomics. This course will cover three areas of the Life Sciences that gained whole new perspectives by the approach and raises new questions to current dogmas: Omics of whole genomes, whole proteomes, and structural proteomics.

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Introduction, Origin of Universe

차시별 강의

1.	Introduction, Origin of Universe	1. Introdution of lecture 2.Origin of Universe(from BigBang to solar system)
	Introduction, Origin of Universe	1. Introdution of lecture 2.Origin of Universe(from BigBang to solar system)
	Introduction, Origin of Universe	1. Introdution of lecture 2.Origin of Universe(from BigBang to solar system)
2.	Origin of life on Earth	1. Origin of life on Earth, How life start of Earth?, Is there life outside Earth?, Was there life outside Earth? 2. Single origin of life(LUCA: last universal common ancester), Evidence for single origin, chemical origin of building bio-blocksnucleotide, amino acids, fatty acis etc. from non-organic meterial), probability(change of certainty)
	Single origin of life	1. Origin of life on Earth, How life start of Earth?, Is there life outside Earth?, Was there life outside Earth? 2. Single origin of life(LUCA: last universal common ancester), Evidence for single origin, chemical origin of building bio-blocksnucleotide, amino acids, fatty acis etc. from non-organic meterial), probability(change of certainty)
3.	Whole Genomes	1.Whole genomes, New era of genomics, Whole genome and epigenome sequences(Genome revolution), Gen-centric view vs Whole genome view, Gene structure of eukaryotes(include human) and composition of genome. 2.Human whole Genome, History of human evolution(composition of Human genome)
	Human whole genome	1.Whole genomes, New era of genomics, Whole genome and epigenome sequences(Genome revolution), Gen-centric view vs Whole genome view, Gene structure of eukaryotes(include human) and composition of genome. 2.Human whole Genome, History of human evolution(composition of Human genome)
4.	1. Human whole genome(continued). 2. Human whole genome features, 2011.	1. Breif history of human genome sequencing, impact of such project. Types of major variation within genome. How the reference sequence derived. 2.Genome anatomy, Introduction of transposon, CNV(copy number variation). Types of polymorphic factors within genome.
	1. Human whole genome(continued). 2. Human whole genome features, 2011.	1. Breif history of human genome sequencing, impact of such project. Types of major variation within genome. How the reference sequence derived. 2.Genome anatomy, Introduction of transposon, CNV(copy number variation). Types of polymorphic factors within genome.
	1. Human whole genome(continued). 2. Human whole genome features, 2011.	1. Breif history of human genome sequencing, impact of such project. Types of major variation within genome. How the reference sequence derived. 2.Genome anatomy, Introduction of transposon, CNV(copy number variation). Types of polymorphic factors within genome.
5.	1. Transposon	1. Introduction of transposon elements(content ratio of transposon in genome). Classification of such elements(class-1 and class-2), Content of each transposon, origin of retrotreansposon(and retrovirus)
	1. Transposon	1. Introduction of transposon elements(content ratio of transposon in genome). Classification of such elements(class-1 and class-2), Content of each transposon, origin of retrotreansposon(and retrovirus)
6.	1.SNP(single nucleotide polymorphism)	1. Introduction of SNP, there are about 3.8M common SNPs in human population), such amount can be(is) reduced by LD(linkage disquilibrium), as SNP blocks, represent in hapmap, Principle of SNP, derive SNP information from sample(micro-array), Haplotype
	1.SNP(single nucleotide polymorphism)	1. Introduction of SNP, there are about 3.8M common SNPs in human population), such amount can be(is) reduced by LD(linkage disquilibrium), as SNP blocks, represent in hapmap, Principle of SNP, derive SNP information from sample(micro-array), Haplotype
7.	1. Introduction of phylogeny tree, 2. Genome diversity of Human, 3. Cancer genome	1. Tree building method(Distance-based and non-distance based), method for estimating support values, basic comcept of tree and term, what is distance matrix, 2. Human population diversity, recent studies based on mitochondria(maternal), Y chromosome(paternal), autosomal genetic marker, migration of human ancester. 3. What is cancer?, Its evolutionary process(natural behavior), mutation of cancer, passenger-driver gene.
	1. Introduction of phylogeny tree, 2. Genome diversity of Human, 3. Cancer genome	1. Tree building method(Distance-based and non-distance based), method for estimating support values, basic comcept of tree and term, what is distance matrix, 2. Human population diversity, recent studies based on mitochondria(maternal), Y chromosome(paternal), autosomal genetic marker, migration of human ancester. 3. What is cancer?, Its evolutionary process(natural behavior), mutation of cancer, passenger-driver gene.
8.	1. Introduction of phylogeny tree, 2. Genome diversity of Human, 3. Cancer genome	1. Tree building method(Distance-based and non-distance based), method for estimating support values, basic comcept of tree and term, what is distance matrix, 2. Human population diversity, recent studies based on mitochondria(maternal), Y chromosome(paternal), autosomal genetic marker, migration of human ancester. 3. What is cancer?, Its evolutionary process(natural behavior), mutation of cancer, passenger-driver gene.