| 1. | |
Aggregation, mechanism of formation, detection and quantitation – size exclusion chromatography, SDS-PAGE, fluorescence spectroscopy, hydrophobic interaction chromatography, laser light scattering, freezing and shaking studies, formulation in detergent, examples trypsin inhibitor, platelet – derived growth factor, fibroblast growth factor. | Aggregation, mechanism of formation, detection and quantitation – size exclusion chromatography, SDS-PAGE, fluorescence spectroscopy, hydrophobic interaction chromatography, laser light scattering, freezing and shaking studies, formulation in detergent, examples trypsin inhibitor, platelet – derived growth factor, fibroblast growth factor. |  |
| 2. | |
Analytical methods for the measurement of the heterogeneity of proteins, product variants and biological sample effects. | Analytical methods for the measurement of the heterogeneity of proteins, product variants and biological sample effects. | |
| 3. | |
Glycoproteins, biosynthetic pathways, protein heterogeneity, biological and medical effects, separations of isoforms and structure determination, HPLC and capillary separations. | Glycoproteins, biosynthetic pathways, protein heterogeneity, biological and medical effects, separations of isoforms and structure determination, HPLC and capillary separations. | |
| 4. | |
Phosphoproteins, biosynthetic pathways, protein heterogeneity, biological and medical effects, separations of isoforms and structure determination, HPLC and capillary separations | Phosphoproteins, biosynthetic pathways, protein heterogeneity, biological and medical effects, separations of isoforms and structure determination, HPLC and capillary separations | |
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