Ever since the wide range applications of laptop computers and cell phones, seeking of power sources for driving portable electronics is becoming increasingly important. The current technology mainly relies on rechargeable batteries. But for the near future, micro/nano-systems will be widely used in health monitoring, infrastructure and environmental monitoring, internet of things and defense technologies; the traditional batteries may not meet or may not be the choice as power sources for the following reasons. First, with the increasingly shrinkage in size, the size of the total micro/nano-systems could be largely dominated by the size of the battery rather than the devices. Second, the number and density of micro/nano-systems to be used for sensor network could be large, thus, replacing batteries for these mobile devices becoming challenging and even impractical. Lastly, the power needed to drive a micro/nano-system is rather small, in the range o f micro- to milli-Watt range. To meet these technological challenges, the author proposed the self-powering nanotechnology in 2005, aiming at harvesting energy from the environment to power the micro/nano-systems based sensor network. This talk will introduce the nanogenerator as a sustainable self-sufficient power source for micro/nano-systems by harvesting energy from our body and living environment.